Towards Optimal Cryoglobulin Recognition and Evaluation

Jeffrey Scott Warren

Abstract


Most patients with clinically significant cryoglobulinemia exhibit rheologic, vasculitic or constitutional findings.  There are several unusual laboratory findings that suggest the possibility of unsuspected cryoglobulinemia.  Specimen collection and laboratory processing errors can lead to inaccurate cryoglobulin evaluation.  Recognition of these unusual laboratory manifestations and rigorous specimen collection, transport and processing will improve the diagnostic evaluation of patients with cryoglobulinemia.


Keywords


cryoglobulin; Brouet classification scheme; monoclonal gammopathy; hepatitis C (HCV); vasculitis; essential mixed cryoglobluinemia; rheumatoid factor (RF)

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DOI: http://dx.doi.org/10.18103/imr.v0i4.68

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