Family of pentatricopeptide repeat proteins in non-plant organisms
Abstract
Pentatricopeptide repeat (PPR) proteins belong to the large family of nucleic acid binding proteins. Their name is defined by the presence of the so-called pentatricopeptide repeat (PPR), a degenerate 35-amino acid motif tandemly repeated 2–26 times per protein. The PPR protein family includes some of the major mediators of organelle post-transcriptional control. These proteins localize mainly to mitochondria and chloroplasts, where they are involved in different steps of RNA metabolism: transcription, splicing, editing, polyadenylation, RNA stability and translation. Some of them can also act as adaptors in protein-protein interactions. PPR protein genes were discovered in many eukaryotic genomes, but they are especially abundant in plants. In humans, some PPR proteins are implicated in human diseases, such as cancer, Alzheimer’s disease and Parkinson’s disease.
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DOI: http://dx.doi.org/10.18103/imr.v4i3.657
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