Skeletal effects of saturated fatty acids
Abstract
Osteoporosis is a bone disease affecting a large population of people worldwide. It is caused by excess bone resorption by osteoclasts over bone formation by osteoblasts. In recent years, growing interest has been seen in fatty acids, the rich component in diets, for their function in regulating bone homeostasis. While unsaturated fatty acids have been intensively studied and many review articles are available on them, this review focuses on saturated fatty acids for their skeletal effects. Many of the studies have found that saturated fatty acids display detrimental effects on bone and bone cells, however the majority of these have been using supra physiological concentrations. We, and others, consistently demonstrate that mid-length saturated fatty acids inhibit osteoclast formation at physiological concentrations and below – a property we are endeavouring to harness in novel osteoporotic therapy. The inhibitory effects are specific to osteoclasts and are not due to cytotoxicity.
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DOI: http://dx.doi.org/10.18103/imr.v3i12.602
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