Fatjon Leti, Johanna K DiStefano


Coronary artery disease (CAD), a group of cardiovascular conditions that develop in response to atherosclerosis, is the most common cause of death worldwide. Atherogenic dyslipidemia, characterized by increased concentrations of circulating small-dense low-density lipoprotein cholesterol (LDL-C) and triglycerides, and decreased levels of high-density lipoprotein cholesterol (HDL-C), is a well-established determinant of heightened CAD risk. To date, several proteins have been found to contribute to the pathogenesis of dyslipidemia. Recently, angiopoietin like 8 (ANGPTL8), which belongs to a family of secreted proteins involved in lipid trafficking and metabolism, has emerged as a novel regulator of triglyceride and HDL-C levels. Here we provide an overview of ANGPTL8 regulation, function, and potential role in atherogenic dyslipidemia. We also present a summary of the evidence supporting genetic factors that contribute to the regulation of ANGPTL8 expression and function. 


ANGPTL8; coronary artery disease; triglycerides, HDL-C, genetics, lipoprotein lipase

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