HCV-associated neurological disorders

Katrin Hahn, Felix Kleefeld


Hepatitis C Virus (HCV) infection might be associated with a number of neurological disorders. Neurological symptoms in HCV infection can either be attributed to immune-related mechanisms, e.g. the production of autoantibodies and cryoglobulins, or directly to the effects of viral cytotoxicity. The most common HCV- associated neurological disorders are distal-symmetric peripheral neuropathies and cognitive deficits. Less common manifestations include demyelinating polyneuropathies (e.g. Guillain-Barré-Syndrome) and inflammation of the muscles (myositis). Newer evidence suggests that HCV infection might also be a risk factor for stroke and Parkinson’s disease. With the emergence of new antiviral drugs, HCV infection can be cured in over 90% of the patients. Thus, the identification of patients suffering from neurological conditions associated with the infection is of major importance as HCV eradication represents a causal treatment for the symptoms of these patients


medical, medicine,research,pharmacology

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DOI: http://dx.doi.org/10.18103/imr.v3i9.546


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