Towards Bio-active Restorative materials with Fucoindan as alternative pit and fissure sealants: in vitro

Abstract

The term pit and fissure sealant is used to describe a material that is introduced into the occlusal pits and fissures of caries–susceptible teeth, thus forming a micromechanical-bonded, protective layer cutting access of caries-producing bacteria from their source of nutrients.  Field of bio-materials has established itself as an integral part of biomedical research development through the focus on designing “smart molecular machines” capable to contain a build in functionality to address specific limitations of the conventional clinical protocols at the molecular level.

Chitosan has been used as a wound dressing material due to its superior tissue- or mucoadhesive property, hemostatic activity, low toxicity, relevant biodegradability and anti-infection activity.[Kim 2008] Chitosan is a cationic polysaccharide and its adhesive properties are mainly based on ionic interactions with tissues or mucus layers.