An Update on Angiotensin-II Mediated Left Ventricular Abnormalities in Chronic Kidney Disease
Abstract
We previously reviewed angiotensin-II (ATII) mediated left ventricular (LV) structural changes in chronic kidney disease (CKD) patients [1]. These changes include myocyte hypertrophy, collagen deposition leading to interstitial fibrosis, and excessive myocardial calcium deposition. This manuscript presents updates on the renin-angiotensin system (RAS) and ATII-mediated LV changes in CKD including the use of speckle tracking echocardiography (STE) in understanding subclinical LV changes in early CKD patients, the role of sympathetic activation via ATII, and ATII-induced gene expression leading to cardiac fibrosis.
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DOI: http://dx.doi.org/10.18103/imr.v3i3.318
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