Longitudinal Follow-up Study of Bone Mineral Density in Adult Survivors of Solid Pediatric Cancers
Abstract
To investigate the hypothesis that abnormal bone mineral density in pediatric solid tumor survivors persists into early adulthood, a follow-up study to our original cross-sectional study was undertaken in two parts. In Part I, the original cohort of 38 patients was updated to include 3 additional patients. The results showed a 34% prevalence of osteopenia and a 12% prevalence of osteoporosis in at least one site.1 The part II study cohort consisted of 14 of the original 38 patients who returned more than 5 years later for repeat dual energy x-ray absorptiometer (DEXA). Overall, during the 5-year interval, 100% of the part II patients showed a decrease in bone mineral density (BMD) at one or more sites and 28.5% showed decreased total body BMD. Statistically significant (p<0.05) overall declines in BMD were seen in the right femoral neck and left distal radius. Young survivors of childhood tumors do not exhibit normal bone mineral density progression and warrant consideration of early preventative intervention.
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Holzer G, Krepler P, et al. Bone mineral density in long-term survivors of highly malignant osteosarcoma. J Bone Joint Surg Br. 2003 Mar;85:231-7.
Lim JS1, Kim DH, Lee JA, Kim DH, Cho J, Cho WH, Lee SY, Jeon DG. Young age at diagnosis, male sex, and decreased lean mass are risk factors of osteoporosis in long-term survivors of osteosarcoma. J Pediatr Hematol Oncol. 2013 Jan;35(1):54-60. doi: 10.1097/MPH.0b013e318275193b.
Müller C1, Winter CC, Rosenbaum D, Boos J, Gosheger G, Hardes J, Vieth V. Early decrements in bone density after completion of neoadjuvant chemotherapy in pediatric bone sarcomapatients. BMC Musculoskelet Disord. 2010 Dec 29;11:287. doi: 10.1186/1471-2474-11-287.
Kaste S, Metzger M, et al. Pediatric Hodgkin lymphoma survivors at negligible risk for significant bone mineral density deficits. Pediatr Blood Cancer. 2009 Apr;52:516-521.
Muszynska-Roslan K, Konstantynowicz J, et al. Is the treatment for childhood solid tumors associated with lower bone mass than that for leukemia and Hodgkin Disease? J Pediatr Hematol Oncol. 2009;26:36-47.
Zhu H, Fang J, et al. Osteoporosis Int. 2009. (Published online)
Gunes A, Can E, et al. Assessment of bone mineral density and risk factors in children completing treatment for acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2010 Apr;32:102-7.
Arikoski P, Komulainen J, Voutilainen R, et al.Reduced bone mineral density in long-term survivors of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 1998;20:234-240.
Gilsanz V, Carlson ME, Roe TF, et al. Osteoporosis after cranial irradiation for acute lymphoblastic leukemia. J Pediatr. 1990;117:238-244.
Hesseling PB, Hough SF, Nel ED, et al. Bone mineral density in long-term survivors of childhood cancer. Int J Cancer Suppl. 1998;11:44-47.
Müller C, Winter C, et al. Early decrements in bone density after completion of neoadjuvant chemotherapy in pediatric bone sarcoma patients. BMC Musculoskeletal Disorders. 2010, 11:287.
DOI: http://dx.doi.org/10.18103/imr.v0i2.23
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