Rapid Progression of a Radiographic Para-bronchial Abnormality after Hip Surgery A Potential Case of Angiogenic Switch/Augmentation in a Patient with Lung Cancer

Ogua Obi, Carlos Anciano, Mark Bowling

Abstract


Most human tumors arise and remain in-situ without progression and angiogenesis for months to years. “Angiogenic Switch” a term coined about 30 years ago, refers to the transition from pre-vascular hyperplasia to highly vascularized and progressively outgrowing tumor. The Angiogenic switch is controlled by changes in the fine-tuned balance between pro- and anti-angiogenic factors secreted either by tumor cells or by cells of the tumor microenvironment. Several pro-angiogenic factors have been elucidated, however emerging evidence shows that bone marrow (BM)-derived endothelial progenitor cells (EPCs) contribute to the angiogenic switch in tumor growth and metastatic progression.  It has been suggested that tissue trauma, as experienced in surgical procedures, may initiate such changes resulting in rapid tumor progression.   We present a case of what we believe to be an angiogenic switch after hip surgery.

Keywords


lung cancer;angiogenesis;metastatic

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DOI: http://dx.doi.org/10.18103/imr.v0i5.124

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