Endoscopic Ultrasound in the Diagnosis of Mucinous Pancreatic Neoplasms

Tony S. Brar, Vikas Khullar, Yaseen Perbtani, Dennis Yang

Abstract


There has been an increased detection of incidental pancreatic cystic neoplasms (PCNs) over recent years. Accurate diagnosis and characterization of these PCNs are essential given their varying potential for malignant transformation. Endoscopic ultrasound (EUS) plays a key role in the evaluation of these lesions; yet, it is not without its limitations. Fluid cytological evaluation is often compromised by the acellular specimen whereas the diagnostic accuracy of chemical and molecular markers is not optimal. More recently, a novel EUS-guided through-the-needle biopsy forceps has been introduced. Potential advantages include targeted tissue sampling and acquisition of larger samples that may allow histological analysis. Further large prospective comparative studies are needed to determine the ideal modality for evaluation of PCNs.


Keywords


Pancreatic Cystic Neoplasms; Endoscopic Ultrasound; Fine Needle Aspiration; Cytology; Chemical Analysis; Molecular Analysis

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References


Lee KS, Sekhar A, Rofsky NM, Pedrosa I. Prevalence of incidental pancreatic cysts in the adult population on MR imaging. Am J Gastroenterol. 2010;105(9):2079-84.

Laffan TA, Horton KM, Klein AP, Berlanstein B, Siegelman SS, Kawamoto S, et al. Prevalence of unsuspected pancreatic cysts on MDCT. AJR Am J Roentgenol. 2008;191(3):802-7.

Kawaguchi Y, Mine T. Endoscopic approach to the diagnosis of pancreatic cystic tumor. World J Gastrointest Oncol. 2016;8(2):159-64.

Chung JW, Chung MJ, Park JY, Bang S, Song SY, Chung JB, et al. Clinicopathologic features and outcomes of pancreatic cysts during a 12-year period. Pancreas. 2013;42(2):230-8.

Klibansky DA, Reid-Lombardo KM, Gordon SR, Gardner TB. The clinical relevance of the increasing incidence of intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol. 2012;10(5):555-8.

Lekkerkerker SJ, Besselink MG, Busch OR, Dijk F, Engelbrecht MR, Rauws EA, et al. Long-term follow-up of neoplastic pancreatic cysts without high-risk stigmata: how often do we change treatment strategy because of malignant transformation? Scand J Gastroenterol. 2016:1-6.

Jacobson BC, Baron TH, Adler DG, Davila RE, Egan J, Hirota WK, et al. ASGE guideline: The role of endoscopy in the diagnosis and the management of cystic lesions and inflammatory fluid collections of the pancreas. Gastrointest Endosc. 2005;61(3):363-70.

Lee LS. Incidental Cystic Lesions in the Pancreas: Resect? EUS? Follow? Curr Treat Options Gastroenterol. 2014;12(3):333-49.

Kadiyala V, Lee LS. Endosonography in the diagnosis and management of pancreatic cysts. World J Gastrointest Endosc. 2015;7(3):213-23.

Chai SM, Herba K, Kumarasinghe MP, de Boer WB, Amanuel B, Grieu-Iacopetta F, et al. Optimizing the multimodal approach to pancreatic cyst fluid diagnosis: developing a volume-based triage protocol. Cancer Cytopathol. 2013;121(2):86-100.

Kim YC, Choi JY, Chung YE, Bang S, Kim MJ, Park MS, et al. Comparison of MRI and endoscopic ultrasound in the characterization of pancreatic cystic lesions. AJR Am J Roentgenol. 2010;195(4):947-52.

Zhong N, Zhang L, Takahashi N, Shalmiyev V, Canto MI, Clain JE, et al. Histologic and imaging features of mural nodules in mucinous pancreatic cysts. Clin Gastroenterol Hepatol. 2012;10(2):192-8, 8.e1-2.

Tanaka M, Fernández-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12(3):183-97.

Tarantino I, Fabbri C, Di Mitri R, Pagano N, Barresi L, Mocciaro F, et al. Complications of endoscopic ultrasound fine needle aspiration on pancreatic cystic lesions: final results from a large prospective multicenter study. Dig Liver Dis. 2014;46(1):41-4.

Layfield LJ, Ehya H, Filie AC, Hruban RH, Jhala N, Joseph L, et al. Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: the Papanicolaou Society of Cytopathology guidelines for pancreatobiliary cytology. Diagn Cytopathol. 2014;42(4):351-62.

Bick BL, Enders FT, Levy MJ, Zhang L, Henry MR, Abu Dayyeh BK, et al. The string sign for diagnosis of mucinous pancreatic cysts. Endoscopy. 2015;47(7):626-31.

Brandone N, Poizat F, Thomassin-Piana J, Turrini O, Popovici C, Terris B. [A solid variant of a serous cystadenocarcinoma of the pancreas]. Ann Pathol. 2016;36(2):125-9.

van der Waaij LA, van Dullemen HM, Porte RJ. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc. 2005;62(3):383-9.

Hong SK, Loren DE, Rogart JN, Siddiqui AA, Sendecki JA, Bibbo M, et al. Targeted cyst wall puncture and aspiration during EUS-FNA increases the diagnostic yield of premalignant and malignant pancreatic cysts. Gastrointest Endosc. 2012;75(4):775-82.

Barresi L, Tarantino I, Traina M, Granata A, Curcio G, Azzopardi N, et al. Endoscopic ultrasound-guided fine needle aspiration and biopsy using a 22-gauge needle with side fenestration in pancreatic cystic lesions. Dig Liver Dis. 2014;46(1):45-50.

Brugge WR, Lewandrowski K, Lee-Lewandrowski E, Centeno BA, Szydlo T, Regan S, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology. 2004;126(5):1330-6.

Nikiforova MN, Khalid A, Fasanella KE, McGrath KM, Brand RE, Chennat JS, et al. Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts. Mod Pathol. 2013;26(11):1478-87.

Dal Molin M, Matthaei H, Wu J, Blackford A, Debeljak M, Rezaee N, et al. Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Ann Surg Oncol. 2013;20(12):3802-8.

Singhi AD, Nikiforova MN, Fasanella KE, McGrath KM, Pai RK, Ohori NP, et al. Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts. Clin Cancer Res. 2014;20(16):4381-9.

Shakhatreh MH, Naini SR, Brijbassie AA, Grider DJ, Shen P, Yeaton P. Use of a novel through-the-needle biopsy forceps in endoscopic ultrasound. Endosc Int Open. 2016;4(4):E439-42.

Coman RM, Schlachterman A, Esnakula AK, Draganov PV, Yang D. EUS-guided, through-the-needle forceps: clenching down the diagnosis. Gastrointest Endosc. 2016.




DOI: http://dx.doi.org/10.18103/imr.v0i5.112

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